January 01, 2018. doi:10.12123/npcd201801005
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Ran Chen, Yi Li, Rennan Weng*
Department of Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510275, P. R . China
Keywords: Nanotechnology; Brain glioma; Treatment
Received: September 01,2017 Accept: November 01,2017 published:January 01,2018
With its highly proliferative, infiltrative, and invasive properties, glioma is the most common malignant primary brain tumor, and 57% of them are glioblastoma multiforme, with a median survival time of only 18 months. However, facing the great challenges from blood-brain barrier and blood-brain tumor barrier, the drug treating for glioma remain non-targeted with low efficiency, which urgently need a new drug. Due to its plastic, low-toxic, targeted nature, nanotechnology brings hope to glioma treatment. In this review, we will discuss the potential possibility of nanoparticles in the treatment of gliomas based on targeted drug delivery system.